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Hide Full Abstract. Visual System. Science Spielen.Com Staff. Asymmetric Unit. Biochemikalien und Reagenzien. Ergebnisse: Genau: Zentrifugen und Mikrozentrifugen Zentrifugen und Mikrozentrifugen Tischzentrifugen.

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To determine the nature of such cues and the mechanisms by which growth cones respond to them, we have analyzed the earliest axonal pathways in the developing spinal cord.

Using in vitro assays in combination with antibodies and molecular markers that define cellular components of the developing spinal cord, we have identified several components of a guidance system that may contribute to the projection pattern of a subset of sensory relay neurons, the commissural neurons.

Commissural neurons project circumferentially and ventrally away from the dorsal midline of the neural tube and towards and across the ventral midline of the spinal cord before turning to project towards higher spinal segments and supraspinal sites.

Two groups of cells, located at the dorsal and ventral midlines and known as the roof plate and the floor plate, respectively, appear to act as sources of cues for commissural axons.

The roof plate appears to direct initial axon extension away from the dorsal midline through the release of a diffusible chemorepellent, whereas the floor plate provides both contact-mediated and diffusible cues for commissural axon navigation towards and across the midline.

We are currently trying to determine how roof plate- and floor plate-derived signals act to influence the direction of growth of commissural axons.

The ventral midline of the neural tube consists of several subgroups of cells that differ, according to their position in the rostro-caudal axis, in the expression of cellular markers and signaling molecules.

Throughout the axis, these cells appear to have multiple roles in the patterning of adjacent cell types and axons. To begin to study the mechanisms underlying cell identity within the neural tube we have therefore examined the development of the ventral midline cell groups.

In particular, FaeG is much larger than other pilins 27 versus approximately 17 kDa , grafting an additional carbohydrate binding domain on the common immunoglobulin-like core.

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Asymmetric Unit. Macromolecule Content Total Structure Weight: SIM only. Mobile Phones. Mobile Broadband. Home Broadband.

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3gew
3gew

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